Going from strength to strength
trial collaborators have already recruited 1,972 patients. This makes
it the largest head injury trial ever conducted. It is well on track
to recruiting the planned 20,000 patients, when compared to other large
simple trials at a similar stage. Figure 1 (right) shows the number
of new hospitals needed to take part in order to reach our target. The
average recruitment of 1.8 patients per hospital per month means that
another 160 hospitals need to take part. If the average rate of recruitment
could be doubled, by ensuring that far fewer eligible patients are missed,
less than 50 new hospitals would be required. Anything that you can
do to increase your recruitment rate or to recruit more hospitals locally
will be very valuable. If you have any ideas for ways in which the Co-ordinating
Centre can help, or strategies that helped you recruit more, then please
let us know.
into trial by hospital
Web access to data for trial collaborators
First 1,000 patients publication
A paper based on the analysis of the first 1,000 patients randomised in the pilot phase has now been written and submitted for publication. As well as describing the design of the MRC CRASH Trial, it also presents baseline data and outcome data (for both treatment groups combined) for the first 1,000 patients. The lead collaborators and nurses of each of the hospitals participating in the pilot phase will be named in the paper. We shall send a copy of the paper to every collaborator as soon as it is published.
Urs Denzler in Kantonsspital Schaffhausen in Switzerland obtained ethics approval and immediately enrolled their first patient into the trial. Also the following centres have now started randomising: Eros Bruzzone and team in Ospedale San Martino, Italy, Juan Carlos Arjona Linares, Hospital Español, Argentina, Walter Videtta, Hospital Nacional Profesor Alejandro Posadas, Argentina and Silvana Svampa, Hospital Provincial Neuquen, Argentina.
Further congratulations go to Mandy Grocutt and Steve Chambers in Worthing Hospital for enrolling their 10th patient and
Other centres to
have previously reached this milestone, as well as other high achievers
are shown on the left.
CRASH Co-ordinating Centre, LSHTM, 49-51 Bedford Square, LONDON
Tel:+44(0)20 7299 4684 Fax:+44(0)20 7299 4663 email: CRASH@lshtm.ac.uk www.crash.lshtm.ac.uk